BIB
Ultra Nasdaq Biotechnology
Investment Objective
ProShares Ultra Nasdaq Biotechnology seeks daily investment results, before fees and expenses, that correspond to two times (2x) the daily performance of the Nasdaq Biotechnology® Index.
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Fund detail sections
Common uses for magnified exposure
Documents & Downloads
You may order paper copies by contacting ProShares Client Services at 866-PRO-5125 (866-776-5125)
Performance
30 Day Daily Return
Chart is updated nightly to reflect the more recent of the previous day's market closing price or the closing price on the day the fund was last traded.
Total Return
Month-End Total Returns as of 8/31/2025
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 9.47% | 28.93% | 1.11% | 9.77% | -16.62% | 3.73% | -4.43% | -2.92% | 14.03% | 04/07/2010 |
| BIB NAV | 9.35% | 28.93% | 1.18% | 9.85% | -16.62% | 3.78% | -4.40% | -2.92% | 14.03% | 04/07/2010 |
| Fund | 1m | 3m | 6m | YTD | 1Y | 3Y | 5Y | 10Y | Since Inception | Inception Date |
|---|---|---|---|---|---|---|---|---|---|---|
| BIB Market Price | 6.88% | -4.57% | -9.00% | -9.00% | -21.42% | -1.05% | -8.38% | -6.36% | 12.80% | 04/07/2010 |
| BIB NAV | 6.82% | -4.48% | -9.00% | -9.00% | -21.46% | -1.12% | -8.40% | -6.35% | 12.79% | 04/07/2010 |
The performance quoted represents past performance and does not guarantee future results. Investment return and principal value of an investment will fluctuate so that an investor's shares, when sold or redeemed, may be worth more or less than the original cost. Shares are bought and sold at market price (not NAV) and are not individually redeemed from the fund. Market price returns are based upon the midpoint of the bid/ask spread at 4:00 p.m. ET (when NAV is normally determined for most funds) and do not represent the returns you would receive if you traded shares at other times. Your brokerage commissions will reduce returns. Current performance may be lower or higher than the performance quoted. For standardized returns and performance data current to the most recent month end, see above.
About the Fund
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Gross Expense Ratio 1.14%
- Net Expense Ratio 0.95%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 9/19/2025- NAV $58.11
- NAV Change $-0.75
- Market Price $58.09
- Market Price Change $-0.75
- Trading Volume (M) 8,441
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Snapshot
- Ticker BIB
- Intraday Ticker BIB.IV
- CUSIP 74347R214
- Inception Date 4/7/10
- Expense Ratio 0.95%
- Gross Expense Ratio 1.14%
- NAV Calculation Time 4:00 p.m. ET
- Distributions Quarterly
- Options Available Yes
Price
as of 9/19/2025- NAV $58.11
- NAV Change $-0.75
- Market Price $58.09
- Market Price Change $-0.75
- Trading Volume (M) 8,441
- 30-Day Median Bid Ask Spread 0.24%
- View Premium / Discount
Expenses with Contractual Waiver through September 30, 2025. Without the fee waiver performance would likely be lower.
Exposures
Index as of 6/30/2025
Holdings
as of 9/19/2025
| Exposure Weight | Ticker | Description | Exposure Value (Notional + GL) |
Market Value | Shares/Contracts | SEDOL Number |
|---|---|---|---|---|---|---|
| 5.21% | GILD | GILEAD SCIENCES INC | -- | $2,934,166.62 | 25,718 | 2369174 |
| 5.11% | AMGN | AMGEN INC | -- | $2,882,070.18 | 10,098 | 2023607 |
| 5.05% | VRTX | VERTEX PHARMACEUTICALS INC | -- | $2,846,581.60 | 7,430 | 2931034 |
| 3.81% | REGN | REGENERON PHARMACEUTICALS | -- | $2,147,147.73 | 3,627 | 2730190 |
| 3.67% | ALNY | ALNYLAM PHARMACEUTICALS INC | -- | $2,070,047.84 | 4,564 | B00FWN1 |
| 2.46% | AZN | ASTRAZENECA PLC-SPONS ADR | -- | $1,386,846.68 | 18,181 | 2989044 |
| 1.91% | INSM | INSMED INC | -- | $1,074,263.96 | 7,421 | 2614487 |
| 1.41% | ARGX | ARGENX SE - ADR | -- | $792,017.00 | 1,075 | BDVLM39 |
| 1.30% | BIIB | BIOGEN INC | -- | $733,447.50 | 5,147 | 2455965 |
| 1.18% | UTHR | UNITED THERAPEUTICS CORP | -- | $663,101.16 | 1,588 | 2430412 |
| 1.05% | INCY | INCYTE CORP | -- | $593,249.68 | 6,856 | 2471950 |
| 0.98% | ILMN | ILLUMINA INC | -- | $554,439.00 | 5,396 | 2613990 |
| 0.98% | RPRX | ROYALTY PHARMA PLC- CL A | -- | $550,014.48 | 15,177 | BMVP7Y0 |
| 0.93% | TEM | TEMPUS AI INC | -- | $522,557.28 | 5,922 | BSLSJJ0 |
| 0.90% | NBIX | NEUROCRINE BIOSCIENCES INC | -- | $505,690.86 | 3,482 | 2623911 |
| 0.87% | SMMT | SUMMIT THERAPEUTICS INC | -- | $492,651.20 | 26,080 | BMTVQS7 |
| 0.87% | MEDP | MEDPACE HOLDINGS INC | -- | $491,619.60 | 986 | BDCBC61 |
| 0.80% | SNY | SANOFI-ADR | -- | $448,625.88 | 9,417 | 2964557 |
| 0.75% | ASND | ASCENDIS PHARMA A/S - ADR | -- | $422,244.48 | 2,136 | BV9G6B8 |
| 0.72% | VTRS | VIATRIS INC | -- | $405,226.80 | 40,932 | BMWS3X9 |
| 0.70% | ONC | BEONE MEDICINES LTD-ADR | -- | $394,592.00 | 1,180 | BYYWPW6 |
| 0.67% | EXEL | EXELIXIS INC | -- | $378,985.10 | 9,451 | 2576941 |
| 0.65% | BMRN | BIOMARIN PHARMACEUTICAL INC | -- | $366,440.76 | 6,741 | 2437071 |
| 0.64% | ROIV | ROIVANT SCIENCES LTD | -- | $360,584.00 | 23,975 | BMW4NZ9 |
| 0.62% | BBIO | BRIDGEBIO PHARMA INC | -- | $351,507.44 | 6,712 | BK1KWG8 |
| 0.61% | MRNA | MODERNA INC | -- | $344,778.40 | 13,660 | BGSXTS3 |
| 0.61% | MDGL | MADRIGAL PHARMACEUTICALS INC | -- | $344,465.19 | 783 | BD59BS7 |
| 0.61% | IONS | IONIS PHARMACEUTICALS INC | -- | $341,411.96 | 5,596 | BDJ0LS6 |
| 0.60% | BNTX | BIONTECH SE-ADR | -- | $339,849.04 | 3,532 | BK6H543 |
| 0.57% | HALO | HALOZYME THERAPEUTICS INC | -- | $319,565.67 | 4,107 | 2975098 |
| 0.56% | VRNA | VERONA PHARMA PLC - ADR | -- | $315,833.58 | 2,979 | BYWPZK5 |
| 0.51% | RVMD | REVOLUTION MEDICINES INC | -- | $285,753.02 | 6,563 | BL71K91 |
| 0.48% | JAZZ | JAZZ PHARMACEUTICALS PLC | -- | $273,279.00 | 2,130 | B4Q5ZN4 |
| 0.46% | GH | GUARDANT HEALTH INC | -- | $258,958.70 | 4,378 | BFXC911 |
| 0.40% | RYTM | RHYTHM PHARMACEUTICALS INC | -- | $224,011.92 | 2,332 | BF2YWG4 |
| 0.36% | CYTK | CYTOKINETICS INC | -- | $204,420.66 | 4,201 | BBBSBJ5 |
| 0.36% | AXSM | AXSOME THERAPEUTICS INC | -- | $203,144.40 | 1,752 | BYZR4X4 |
| 0.35% | CRSP | CRISPR THERAPEUTICS AG | -- | $198,987.76 | 3,193 | BDHF4K6 |
| 0.33% | RNA | AVIDITY BIOSCIENCES INC | -- | $185,468.02 | 4,517 | BMWHPY1 |
| 0.32% | MRUS | MERUS NV | -- | $181,124.10 | 2,655 | BZBY005 |
| 0.32% | NUVL | NUVALENT INC-A | -- | $179,484.47 | 2,341 | BMVBZD3 |
| 0.30% | PTCT | PTC THERAPEUTICS INC | -- | $168,678.72 | 2,789 | B17VCN9 |
| 0.29% | KRYS | KRYSTAL BIOTECH INC | -- | $166,187.12 | 1,016 | BD6JX35 |
| 0.29% | ALKS | ALKERMES PLC | -- | $161,070.84 | 5,796 | B3P6D26 |
| 0.27% | ACLX | ARCELLX INC | -- | $151,593.42 | 1,947 | BPCJ1Q2 |
| 0.26% | ARWR | ARROWHEAD PHARMACEUTICALS IN | -- | $148,969.26 | 4,854 | BYQBFJ8 |
| 0.26% | PCVX | VAXCYTE INC | -- | $144,716.50 | 4,558 | BKPVGH6 |
| 0.26% | ACAD | ACADIA PHARMACEUTICALS INC | -- | $144,639.66 | 5,923 | 2713317 |
| 0.24% | PTGX | PROTAGONIST THERAPEUTICS INC | -- | $135,844.80 | 2,184 | BDCBCD8 |
| 0.24% | ADMA | ADMA BIOLOGICS INC | -- | $133,293.98 | 8,378 | B9NSBM2 |
| 0.23% | MIRM | MIRUM PHARMACEUTICALS INC | -- | $131,206.32 | 1,764 | BJDX8Y8 |
| 0.23% | AKRO | AKERO THERAPEUTICS INC | -- | $126,977.76 | 2,808 | BK7Y2V9 |
| 0.22% | KYMR | KYMERA THERAPEUTICS INC | -- | $123,316.30 | 2,510 | BMPRZV5 |
| 0.20% | LGND | LIGAND PHARMACEUTICALS | -- | $114,558.88 | 688 | 2501578 |
| 0.20% | CRNX | CRINETICS PHARMACEUTICALS IN | -- | $112,106.46 | 3,306 | BDD19F8 |
| 0.19% | AMRX | AMNEAL PHARMACEUTICALS INC | -- | $108,174.87 | 11,027 | BFNF1D6 |
| 0.19% | -- | NEWAMSTERDAM PHARMA CO NV | -- | $105,532.26 | 3,954 | BP8JSP4 |
| 0.18% | SRRK | SCHOLAR ROCK HOLDING CORP | -- | $104,085.00 | 3,375 | BFZQ0L8 |
| 0.18% | APLS | APELLIS PHARMACEUTICALS INC | -- | $102,026.34 | 4,434 | BYTQ6X1 |
| 0.18% | LEGN | LEGEND BIOTECH CORP-ADR | -- | $100,533.56 | 2,956 | BMX9K07 |
| 0.18% | XENE | XENON PHARMACEUTICALS INC | -- | $100,023.65 | 2,707 | BRJ3GY4 |
| 0.18% | CGON | CG ONCOLOGY INC | -- | $98,781.30 | 2,677 | BRBCSP4 |
| 0.17% | INDV | INDIVIOR PLC | -- | $98,616.31 | 4,381 | BP0BQQ5 |
| 0.17% | RARE | ULTRAGENYX PHARMACEUTICAL IN | -- | $95,163.79 | 3,383 | BJ62Z18 |
| 0.17% | VCYT | VERACYTE INC | -- | $94,211.82 | 2,762 | BFTWZY0 |
| 0.16% | MLYS | MINERALYS THERAPEUTICS INC | -- | $91,420.56 | 2,328 | BP9N0G0 |
| 0.16% | SUPN | SUPERNUS PHARMACEUTICALS INC | -- | $90,652.76 | 1,969 | B72ZBG4 |
| 0.16% | IBRX | IMMUNITYBIO INC | -- | $90,600.51 | 33,187 | BNSP0B8 |
| 0.16% | IMVT | IMMUNOVANT INC | -- | $90,453.60 | 6,120 | BJRFSB7 |
| 0.16% | FOLD | AMICUS THERAPEUTICS INC | -- | $90,147.26 | 10,822 | B19FQ48 |
| 0.15% | ALVO | ALVOTECH SA | -- | $86,601.20 | 10,990 | BPNTJ34 |
| 0.15% | BEAM | BEAM THERAPEUTICS INC | -- | $86,384.64 | 3,552 | BK6L288 |
| 0.14% | TARS | TARSUS PHARMACEUTICALS INC | -- | $81,510.00 | 1,482 | BMH5RL1 |
| 0.14% | IDYA | IDEAYA BIOSCIENCES INC | -- | $79,201.98 | 3,077 | BK0VHF6 |
| 0.14% | TVTX | TRAVERE THERAPEUTICS INC | -- | $77,780.50 | 3,130 | BLFGJD5 |
| 0.14% | ETNB | 89BIO INC | -- | $77,428.09 | 5,207 | BK1K484 |
| 0.14% | AGIO | AGIOS PHARMACEUTICALS INC | -- | $76,908.00 | 2,040 | BCBVTX1 |
| 0.14% | CNTA | CENTESSA PHARMACEUTICALS-ADR | -- | $76,756.72 | 3,368 | BLB0YQ9 |
| 0.13% | IRON | DISC MEDICINE INC | -- | $74,224.59 | 1,221 | BMGJZJ8 |
| 0.13% | OCUL | OCULAR THERAPEUTIX INC | -- | $73,918.90 | 6,109 | BNZB1X8 |
| 0.13% | RXRX | RECURSION PHARMACEUTICALS-A | -- | $73,659.82 | 15,002 | BM9FJ13 |
| 0.13% | ANIP | ANI PHARMACEUTICALS INC | -- | $73,657.19 | 761 | BCDWBX6 |
| 0.13% | ARQT | ARCUTIS BIOTHERAPEUTICS INC | -- | $73,169.80 | 4,210 | BKX9VD3 |
| 0.13% | ADPT | ADAPTIVE BIOTECHNOLOGIES | -- | $71,422.56 | 5,346 | BJ5FZ74 |
| 0.12% | HRMY | HARMONY BIOSCIENCES HOLDINGS | -- | $65,730.80 | 2,020 | BKSGZN7 |
| 0.12% | DYN | DYNE THERAPEUTICS INC | -- | $65,584.35 | 4,995 | BN15WD1 |
| 0.12% | DNLI | DENALI THERAPEUTICS INC | -- | $65,445.75 | 5,133 | BD2B4V0 |
| 0.11% | AUPH | AURINIA PHARMACEUTICALS INC | -- | $60,073.00 | 4,621 | BFWLC09 |
| 0.11% | SRPT | SAREPTA THERAPEUTICS INC | -- | $59,802.33 | 3,431 | B8DPDT7 |
| 0.10% | APGE | APOGEE THERAPEUTICS INC | -- | $59,142.07 | 1,619 | BM9HHL5 |
| 0.10% | TWST | TWIST BIOSCIENCE CORP | -- | $59,015.24 | 2,116 | BGKG6G7 |
| 0.10% | NTLA | INTELLIA THERAPEUTICS INC | -- | $58,758.71 | 3,769 | BYZM6C2 |
| 0.10% | COGT | COGENT BIOSCIENCES INC | -- | $58,712.85 | 4,905 | BLR6XK8 |
| 0.10% | MNKD | MANNKIND CORP | -- | $58,491.96 | 10,772 | BF081J4 |
| 0.10% | HROW | HARROW INC | -- | $57,597.66 | 1,299 | BHNDW86 |
| 0.10% | VERA | VERA THERAPEUTICS INC | -- | $57,347.19 | 2,241 | BL55460 |
| 0.10% | BCRX | BIOCRYST PHARMACEUTICALS INC | -- | $56,749.00 | 7,370 | 2100362 |
| 0.10% | VCEL | VERICEL CORP | -- | $56,136.96 | 1,772 | BSBMN89 |
| 0.10% | AVDL | AVADEL PHARMACEUTICALS | -- | $55,225.80 | 3,409 | BDGMC59 |
| 0.10% | ZLAB | ZAI LAB LTD-ADR | -- | $54,819.35 | 1,679 | BD9GVY0 |
| 0.10% | KNSA | KINIKSA PHARMACEUTICALS INTE | -- | $54,050.92 | 1,526 | BRXB0C0 |
| 0.09% | EWTX | EDGEWISE THERAPEUTICS INC | -- | $52,747.74 | 3,699 | BKY5JZ8 |
| 0.09% | GRAL | GRAIL INC | -- | $52,728.90 | 1,266 | BSLSSX7 |
| 0.09% | ARDX | ARDELYX INC | -- | $52,542.81 | 8,461 | BN89V40 |
| 0.09% | TXG | 10X GENOMICS INC-CLASS A | -- | $52,381.68 | 4,017 | BKS3RS7 |
| 0.09% | NVCR | NOVOCURE LTD | -- | $49,808.25 | 3,925 | BYSS4X4 |
| 0.09% | NVAX | NOVAVAX INC | -- | $49,664.42 | 5,702 | BJDQXG4 |
| 0.09% | JANX | JANUX THERAPEUTICS INC | -- | $49,479.50 | 2,110 | BMFX8Y7 |
| 0.09% | GPCR | STRUCTURE THERAPEUTICS INC | -- | $49,329.36 | 2,092 | BQS9486 |
| 0.08% | ABCL | ABCELLERA BIOLOGICS INC | -- | $47,318.92 | 10,492 | BL53SR3 |
| 0.08% | IMCR | IMMUNOCORE HOLDINGS PLC-ADR | -- | $45,835.60 | 1,406 | BLCD809 |
| 0.08% | AMPH | AMPHASTAR PHARMACEUTICALS IN | -- | $45,108.48 | 1,632 | BNFWZS4 |
| 0.08% | SNDX | SYNDAX PHARMACEUTICALS INC | -- | $44,694.72 | 3,024 | BN7Q7R7 |
| 0.08% | STOK | STOKE THERAPEUTICS INC | -- | $44,105.40 | 1,926 | BJQ05Z6 |
| 0.08% | XERS | XERIS BIOPHARMA HOLDINGS INC | -- | $43,764.68 | 5,669 | BLR7H87 |
| 0.08% | TRML | TOURMALINE BIO INC | -- | $43,052.46 | 902 | BQ80NC6 |
| 0.08% | ZYME | ZYMEWORKS INC | -- | $42,883.75 | 2,639 | BPCQZY9 |
| 0.08% | INVA | INNOVIVA INC | -- | $42,467.47 | 2,213 | BDDXF67 |
| 0.08% | LENZ | LENZ THERAPEUTICS INC | -- | $42,312.27 | 1,001 | BQV0J03 |
| 0.08% | CVAC | CUREVAC NV | -- | $42,291.75 | 7,905 | BN4RD42 |
| 0.07% | PCRX | PACIRA BIOSCIENCES INC | -- | $42,069.48 | 1,578 | B3X26D8 |
| 0.07% | GRFS | GRIFOLS SA-ADR | -- | $41,716.42 | 4,283 | B8K7T65 |
| 0.07% | AMLX | AMYLYX PHARMACEUTICALS INC | -- | $41,673.61 | 3,131 | BPCK358 |
| 0.07% | GMAB | GENMAB A/S -SP ADR | -- | $41,628.16 | 1,472 | BBC9WC7 |
| 0.07% | DVAX | DYNAVAX TECHNOLOGIES CORP | -- | $39,893.73 | 4,117 | BRJZSK0 |
| 0.07% | COLL | COLLEGIUM PHARMACEUTICAL INC | -- | $39,539.50 | 1,106 | BX7RSN3 |
| 0.07% | ELVN | ENLIVEN THERAPEUTICS INC | -- | $39,436.80 | 2,080 | BMFD115 |
| 0.07% | PGEN | PRECIGEN INC | -- | $39,228.75 | 10,461 | BKM5C84 |
| 0.07% | WVE | WAVE LIFE SCIENCES LTD | -- | $38,494.43 | 5,587 | BYZG9R0 |
| 0.06% | ORIC | ORIC PHARMACEUTICALS INC | -- | $36,072.96 | 3,416 | BKVDFF7 |
| 0.06% | TRVI | TREVI THERAPEUTICS INC | -- | $34,841.25 | 4,275 | BJH9ZN0 |
| 0.06% | SPRY | ARS PHARMACEUTICALS INC | -- | $33,932.14 | 3,466 | BMCR7V2 |
| 0.06% | RAPP | RAPPORT THERAPEUTICS INC | -- | $33,767.16 | 1,281 | BR3T9B6 |
| 0.06% | FTRE | FORTREA HOLDINGS INC | -- | $32,294.44 | 3,188 | BRXYZ57 |
| 0.06% | EYPT | EYEPOINT PHARMACEUTICALS INC | -- | $32,065.00 | 2,420 | BMGS7L1 |
| 0.06% | SYRE | SPYRE THERAPEUTICS INC | -- | $31,560.48 | 2,121 | BQBBDY8 |
| 0.06% | PRAX | PRAXIS PRECISION MEDICINES I | -- | $31,200.58 | 739 | BQ721R4 |
| 0.05% | PRME | PRIME MEDICINE INC | -- | $30,019.71 | 6,139 | BPBJFM7 |
| 0.05% | TNGX | TANGO THERAPEUTICS INC | -- | $29,685.60 | 3,906 | BP2P6L0 |
| 0.05% | GERN | GERON CORP | -- | $29,568.00 | 22,400 | 2370381 |
| 0.05% | CRMD | CORMEDIX INC | -- | $29,355.20 | 2,621 | BJ0LT31 |
| 0.05% | URGN | UROGEN PHARMA LTD | -- | $29,132.85 | 1,623 | BZ7PJQ1 |
| 0.05% | ABUS | ARBUTUS BIOPHARMA CORP | -- | $28,602.50 | 6,730 | BZ0QMB7 |
| 0.05% | PAHC | PHIBRO ANIMAL HEALTH CORP-A | -- | $28,499.90 | 715 | BL95N25 |
| 0.05% | RLAY | RELAY THERAPEUTICS INC | -- | $28,206.98 | 6,053 | BN2R582 |
| 0.05% | MESO | MESOBLAST LTD- SPON ADR | -- | $28,202.58 | 1,658 | BQS7491 |
| 0.05% | SANA | SANA BIOTECHNOLOGY INC | -- | $28,066.47 | 9,083 | BMFJJ97 |
| 0.05% | PHAT | PHATHOM PHARMACEUTICALS INC | -- | $27,924.11 | 2,491 | BJLKVS6 |
| 0.05% | TSHA | TAYSHA GENE THERAPIES INC | -- | $27,102.91 | 9,577 | BNC1BX1 |
| 0.05% | QURE | UNIQURE NV | -- | $26,713.62 | 1,926 | BJFSR88 |
| 0.05% | IOVA | IOVANCE BIOTHERAPEUTICS INC | -- | $26,043.20 | 12,704 | BF0DMK7 |
| 0.05% | XNCR | XENCOR INC | -- | $25,766.16 | 2,504 | BGCYWN8 |
| 0.05% | AVXL | ANAVEX LIFE SCIENCES CORP | -- | $25,515.36 | 3,016 | BYTYP72 |
| 0.04% | VIR | VIR BIOTECHNOLOGY INC | -- | $25,262.86 | 4,877 | BK4PZ38 |
| 0.04% | KURA | KURA ONCOLOGY INC | -- | $25,137.75 | 3,047 | BYZD465 |
| 0.04% | AVBP | ARRIVENT BIOPHARMA INC | -- | $25,133.60 | 1,424 | BMGTLY5 |
| 0.04% | CSTL | CASTLE BIOSCIENCES INC | -- | $24,849.38 | 1,018 | BKLCWZ3 |
| 0.04% | TBPH | THERAVANCE BIOPHARMA INC | -- | $24,539.84 | 1,768 | BMNDK09 |
| 0.04% | DAWN | DAY ONE BIOPHARMACEUTICALS I | -- | $24,488.76 | 3,596 | BLB0YH0 |
| 0.04% | MNMD | MIND MEDICINE MINDMED INC | -- | $24,145.84 | 2,671 | BPQYY97 |
| 0.04% | AQST | AQUESTIVE THERAPEUTICS INC | -- | $24,080.49 | 4,247 | BYVQJ96 |
| 0.04% | TYRA | TYRA BIOSCIENCES INC | -- | $23,387.50 | 1,871 | BMVNDH9 |
| 0.04% | KALV | KALVISTA PHARMACEUTICALS INC | -- | $23,271.39 | 1,767 | BD06CS0 |
| 0.04% | TERN | TERNS PHARMACEUTICALS INC | -- | $23,132.16 | 3,072 | BMDJ0C9 |
| 0.04% | NRIX | NURIX THERAPEUTICS INC | -- | $22,627.64 | 2,681 | BMVLGP2 |
| 0.04% | KROS | KEROS THERAPEUTICS INC | -- | $22,188.56 | 1,426 | BM7V485 |
| 0.04% | SIGA | SIGA TECHNOLOGIES INC | -- | $22,072.92 | 2,514 | 2107437 |
| 0.04% | RIGL | RIGEL PHARMACEUTICALS INC | -- | $21,873.60 | 630 | BQD3J33 |
| 0.04% | SVRA | SAVARA INC | -- | $21,420.04 | 6,068 | BYXGN81 |
| 0.04% | MGTX | MEIRAGTX HOLDINGS PLC | -- | $21,349.44 | 2,824 | BFYQFJ2 |
| 0.04% | ANAB | ANAPTYSBIO INC | -- | $20,485.72 | 983 | BDRW1L7 |
| 0.04% | ORKA | ORUKA THERAPEUTICS INC | -- | $20,448.25 | 1,315 | BKVF0J2 |
| 0.03% | OLMA | OLEMA PHARMACEUTICALS INC | -- | $19,689.70 | 2,410 | BMZ4LN0 |
| 0.03% | ARCT | ARCTURUS THERAPEUTICS HOLDIN | -- | $19,498.38 | 953 | BKC9SX3 |
| 0.03% | ARVN | ARVINAS INC | -- | $19,386.56 | 2,578 | BDZ30Q0 |
| 0.03% | PSNL | PERSONALIS INC | -- | $18,989.30 | 3,113 | BJQ0608 |
| 0.03% | ESPR | ESPERION THERAPEUTICS INC | -- | $18,830.14 | 7,079 | BBNBTD2 |
| 0.03% | HCM | HUTCHMED CHINA-ADR | -- | $18,556.56 | 1,089 | BYXV9H7 |
| 0.03% | ERAS | ERASCA INC | -- | $18,324.56 | 9,959 | BNLYBF3 |
| 0.03% | GLPG | GALAPAGOS NV-SPON ADR | -- | $17,172.42 | 503 | B292NQ7 |
| 0.03% | CMPS | COMPASS PATHWAYS PLC | -- | $15,778.00 | 3,220 | BMC3HS7 |
| 0.03% | RGNX | REGENXBIO INC | -- | $15,761.97 | 1,773 | BZ0G875 |
| 0.03% | CRVS | CORVUS PHARMACEUTICALS INC | -- | $15,355.92 | 2,616 | BYP80F1 |
| 0.03% | PRTA | PROTHENA CORP PLC | -- | $15,252.30 | 1,890 | B91XRN2 |
| 0.03% | LXRX | LEXICON PHARMACEUTICALS INC | -- | $15,182.02 | 12,758 | BWFZX59 |
| 0.03% | ZVRA | ZEVRA THERAPEUTICS INC | -- | $15,117.57 | 1,971 | BLFBZ32 |
| 0.03% | EOLS | EVOLUS INC | -- | $14,284.59 | 2,271 | BDRJH21 |
| 0.03% | ALMS | ALUMIS INC | -- | $14,182.17 | 3,401 | BPLQG36 |
| 0.02% | INBX | INHIBRX BIOSCIENCES INC | -- | $14,048.40 | 509 | BNSP8K3 |
| 0.02% | SLDB | SOLID BIOSCIENCES INC | -- | $13,998.08 | 2,734 | BQHN6C7 |
| 0.02% | ATXS | ASTRIA THERAPEUTICS INC | -- | $13,966.05 | 1,981 | BMYRFN8 |
| 0.02% | GLUE | MONTE ROSA THERAPEUTICS INC | -- | $13,723.44 | 2,168 | BP7KZP7 |
| 0.02% | ABSI | ABSCI CORP | -- | $13,702.50 | 5,250 | BN94K69 |
| 0.02% | MRVI | MARAVAI LIFESCIENCES HLDGS-A | -- | $13,689.00 | 5,070 | BMCWKZ2 |
| 0.02% | PACB | PACIFIC BIOSCIENCES OF CALIF | -- | $13,393.42 | 10,546 | B4N8MH9 |
| 0.02% | AURA | AURA BIOSCIENCES INC | -- | $13,260.48 | 2,181 | BP81R42 |
| 0.02% | CGEM | CULLINAN THERAPEUTICS INC | -- | $12,858.80 | 2,074 | BM90J52 |
| 0.02% | LRMR | LARIMAR THERAPEUTICS INC | -- | $12,621.00 | 3,005 | BMXNGZ6 |
| 0.02% | DSGN | DESIGN THERAPEUTICS INC | -- | $12,093.95 | 1,999 | BMFK3H6 |
| 0.02% | ALT | ALTIMMUNE INC | -- | $11,714.22 | 3,099 | BFY7DC4 |
| 0.02% | RCKT | ROCKET PHARMACEUTICALS INC | -- | $11,629.16 | 3,788 | BDFKQ07 |
| 0.02% | BCYC | BICYCLE THERAPEUTICS PLC-ADR | -- | $11,247.39 | 1,623 | BKDQKM6 |
| 0.02% | ANNX | ANNEXON INC | -- | $11,033.88 | 3,858 | BMVV9R5 |
| 0.02% | AMRN | AMARIN CORP PLC -ADR | -- | $10,867.80 | 708 | BN72KB0 |
| 0.02% | FDMT | 4D MOLECULAR THERAPEUTICS IN | -- | $10,824.00 | 1,640 | BKLXFX5 |
| 0.02% | ALEC | ALECTOR INC | -- | $10,765.59 | 3,553 | BJ4LDC4 |
| 0.02% | SCPH | SCPHARMACEUTICALS INC | -- | $10,533.73 | 1,871 | BYX2Z16 |
| 0.02% | HUMA | HUMACYTE INC | -- | $10,341.60 | 5,560 | BMYTJP4 |
| 0.02% | NMRA | NEUMORA THERAPEUTICS INC | -- | $10,007.36 | 5,686 | BN4JN37 |
| 0.02% | FHTX | FOGHORN THERAPEUTICS INC | -- | $10,004.86 | 1,993 | BMF7DT9 |
| 0.02% | OMER | OMEROS CORP | -- | $9,986.02 | 2,389 | B4NB858 |
| 0.02% | TECX | TECTONIC THERAPEUTIC INC | -- | $9,841.86 | 657 | BPBPCG8 |
| 0.02% | LXEO | LEXEO THERAPEUTICS INC | -- | $9,738.65 | 1,891 | BQ6C357 |
| 0.02% | AUTL | AUTOLUS THERAPEUTICS PLC | -- | $9,436.28 | 7,042 | BFMLGR4 |
| 0.02% | VNDA | VANDA PHARMACEUTICALS INC | -- | $9,316.75 | 2,075 | B12W3P6 |
| 0.02% | ALLO | ALLOGENE THERAPEUTICS INC | -- | $9,036.40 | 7,790 | BFZNYB7 |
| 0.02% | EDIT | EDITAS MEDICINE INC | -- | $8,934.31 | 3,157 | BZ8FPH3 |
| 0.02% | REPL | REPLIMUNE GROUP INC | -- | $8,836.50 | 2,740 | BDDVW37 |
| 0.02% | LYEL | LYELL IMMUNOPHARMA INC | -- | $8,822.66 | 674 | BTNMG41 |
| 0.02% | KYTX | KYVERNA THERAPEUTICS INC | -- | $8,804.40 | 1,518 | BSMLR16 |
| 0.02% | TKNO | ALPHA TEKNOVA INC | -- | $8,718.56 | 1,879 | BP7L561 |
| 0.02% | ACIU | AC IMMUNE SA | -- | $8,636.25 | 3,525 | BZC0D70 |
| 0.02% | RNAC | CARTESIAN THERAPEUTICS INC | -- | $8,618.72 | 913 | BQB9HM8 |
| 0.02% | NGNE | NEUROGENE INC | -- | $8,617.20 | 501 | BS2F741 |
| 0.01% | VYGR | VOYAGER THERAPEUTICS INC | -- | $8,313.69 | 1,947 | BY7RB53 |
| 0.01% | SLN | SILENCE THERAPEUTICS PLC-ADR | -- | $8,063.61 | 1,649 | BL5B6Z1 |
| 0.01% | IRWD | IRONWOOD PHARMACEUTICALS INC | -- | $8,041.23 | 5,703 | B3MZ6K5 |
| 0.01% | AVIR | ATEA PHARMACEUTICALS INC | -- | $8,023.68 | 2,786 | BLN9Z50 |
| 0.01% | CCCC | C4 THERAPEUTICS INC | -- | $7,896.84 | 2,499 | BKX9NQ0 |
| 0.01% | CDXS | CODEXIS INC | -- | $7,764.05 | 3,169 | B5LL2C2 |
| 0.01% | TRDA | ENTRADA THERAPEUTICS INC | -- | $7,235.70 | 1,335 | BP81RK8 |
| 0.01% | OABI | OMNIAB INC | -- | $6,935.88 | 4,308 | BN13S71 |
| 0.01% | ENTA | ENANTA PHARMACEUTICALS INC | -- | $5,737.64 | 751 | B9L5200 |
| 0.01% | MXCT | MAXCYTE INC | -- | $5,689.36 | 3,743 | BKMQF66 |
| 0.01% | CLYM | CLIMB BIO INC | -- | $5,495.49 | 2,379 | BMW5LX6 |
| 0.01% | TVGN | TEVOGEN BIO HOLDINGS INC | -- | $5,237.51 | 6,906 | BPG5P75 |
| 0.01% | NKTX | NKARTA INC | -- | $4,988.00 | 2,494 | BK80YJ8 |
| 0.01% | PYXS | PYXIS ONCOLOGY INC | -- | $4,898.25 | 2,177 | BLBR8D5 |
| 0.01% | BMEA | BIOMEA FUSION INC | -- | $4,073.55 | 2,089 | BNKF6N0 |
| 0.01% | FATE | FATE THERAPEUTICS INC | -- | $3,896.35 | 4,049 | BCZS820 |
| 0.01% | MGNX | MACROGENICS INC | -- | $3,594.78 | 2,219 | BFDV8K0 |
| 0.01% | TCRX | TSCAN THERAPEUTICS INC | -- | $3,297.18 | 1,842 | BNLYBJ7 |
| 0.01% | PLRX | PLIANT THERAPEUTICS INC | -- | $3,081.65 | 2,155 | BMDWW66 |
| -- | STRO | SUTRO BIOPHARMA INC | -- | $2,638.52 | 2,976 | BF12XC2 |
| -- | ARTV | ARTIVA BIOTHERAPEUTICS INC | -- | $2,471.04 | 858 | BMF1LJ7 |
| -- | APLT | APPLIED THERAPEUTICS INC | -- | $2,197.84 | 5,056 | BJL38Z1 |
| -- | PEPG | PEPGEN INC | -- | $2,165.76 | 1,152 | BMTX3D7 |
| -- | ACRV | ACRIVON THERAPEUTICS INC | -- | $1,799.52 | 1,104 | BP2TPK4 |
| -- | MRSN | MERSANA THERAPEUTICS INC | -- | $1,268.75 | 175 | BVPKH99 |
| -- | OKUR | ONKURE THERAPEUTICS INC-A | -- | $1,159.07 | 451 | BT7KGT6 |
| -- | QTTB | Q32 BIO INC | -- | $791.80 | 428 | BS2FKQ4 |
| -- | 2324462D | CARTESIAN THERAPEUTICS-CVR | -- | $00.00 | 9,785 | BM9HFX3 |
| -- | THRD | THIRD HARMONIC BIO INC | -- | $00.00 | 1,662 | BNNPQY8 |
| 31.35% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP UBS AG | 17,667,710 | -- | 3,675 | -- |
| 26.10% | -- | NASDAQ BIO INDEX SWAP BNP PARIBAS | 14,711,072 | -- | 3,060 | -- |
| 24.46% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP CITIBANK NA | 13,788,025 | -- | 2,868 | -- |
| 19.40% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP BANK OF AMERICA NA | 10,932,346 | -- | 2,274 | -- |
| 16.41% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP SOCIETE GENERALE | 9,249,707 | -- | 1,924 | -- |
| 16.37% | -- | NASDAQ BIOTECHNOLOGY INDEX SWAP GOLDMAN SACHS INTERNATIONAL | 9,225,669 | -- | 1,919 | -- |
| -- | -- | TREASURY BILL | -- | $4,990,495.75 | 5,000,000 | BRF3QJ3 |
| -- | -- | NET OTHER ASSETS (LIABILITIES) | -- | $14,095,240.76 | 14,095,241 | -- |
Index
as of 6/30/2025
- Total Number of Companies260
- Price/Book Ratio3.78
- Dividend Yield ( % )0.85
- Avg. Index Market Capitalization$5.68 billion
About the Index
The Nasdaq Biotechnology Index is designed to measure the performance of a set of Nasdaq-listed biotechnology and pharmaceutical companies.
Distributions
For
2025
- 2025
- 2024
- 2023
- 2022
| Ex-Dividend Date | Record Date | Payable Date | Dividend | Long-Term Capital Gain | Short-Term Capital Gain | Return of Capital |
|---|
Portfolio Hedging Series
Part I: The Significance of Portfolio Hedging
Investing involves risk. Market downturns will happen. Having a sound investment strategy can help smooth out the turbulence in your portfolio and save you from getting caught up in a herd mentality of selling low into a down market.
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